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Using primary, fully matured HBE cells grown at the air liquid interface exposed to mainstream smoke from tobacco cigarettes, this study evaluated activation of the parthanatos pathway by measuring the mitochondrial to nuclear translocation of AIF and EndoG

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Horn himself believed that if an outright ban on cigarette advertising could not be achieved, confining the advertising that was done to low-tar-and-nicotine brands had some value, since his own research on smoking habits had shown that for some habitual smokers a switch from high- to low-tar-and-nicotine cigarettes was a way station toward ridding themselves of the habit altogether

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